Hypoestrogenism

Hypoestrogenism or Estrogen Deficiency is an intersex variation in which one has low estrogenic activity within their body. It can affect both CTF and CTM individuals alike.

In CTF individuals, symptoms may include physical and chemical changes of the vulva/vagina, hot flashes, and amenorrhea.

For both CTF and CTM individuals, symptoms may include hot flashes, sleeping disturbances, decreased bone health, changes in the genitourinary system, pain during sexual intercourse, a lower urinary tract, and defects in bone health (which may result in scoliosis, bone resorption, type I osteoporosis, fractures, and low bone density). Infertility may occur.

CTM individuals with this variation also have aromatase deficiency and/or estrogen insensitivity syndrome in many cases.

Causes
Hypoestrogenism can be caused by hypogonadism (both müllerian hypogonadism and wolffian hypogonadism) and/or certain medications. For CTF individuals, menopause, functional amenorrhea, and/or primary ovarian insufficiency may be the cause of this variation.