#REDIRECT [[XXXXY Syndrome]]
{{Copied|original=LGBTA Wiki}}
[[File:49 2cxxxxy Syndrome.png|alt=|thumb|The 49,XXXXY Syndrome flag.]]
'''49,XXXXY syndrome,''' also sometimes known as '''Fraccaro Syndrome''', is an extremely rare [[intersex]] variation in [[AMAB]] or [[CTM]] individuals in which they have three extra X chromosomes. It occurs in approximately 1 out of 85,000 - 100,000 AMAB individuals.
Symptoms of 49,XXXXY syndrome can vary, but it usually includes learning difficulties/intellectual disabilities, [[Secondary Sex Agenesis|low muscle tone]], [[AMAB Hypogonadism|hypogonadism]], infertility, delayed growth, dental issues, curved pinky fingers, a variety of birth defects that may affect the heart, bones, brain and/or kidneys, and distinctive facial features such as widely spaced eyes, a flat nose bridge, and epicanthal folds.
One common symptom is an [[Agenital|undergrown penis (micropenis) or undescended testicles (cryptorchidism.)]] This often causes them not to produce as much testosterone, often leading them to not grow much body hair and not have many masculine traits. This may also cause an over production of estrogen, which may cause them to also fall under [[aromatase excess syndrome]]] and/or [[AMAB Hypogonadism]].
Those with this variation likely end up being neurodivergent with intellectual disabilities, and because of this, many can understand what other people say more easily than they themselves can speak.
It is important to note that not all the symptoms listed above are guaranteed to occur in someone with this variation, as someone may only experience one or several of these symptoms, yet still hold the variation.
==History==
It was first diagnosed in 1960, and was named Fraccaro syndrome after the individual who researched it.
==Flag==
The flag was created by FANDOM user Thepartyboy607 on March 15th of 2021. The greens are for facial features, yellow is for the intersex spectrum, light orange is for chromosomal abnormality, and the rest of the oranges are for community.
==Resources==
*https://en.wikipedia.org/wiki/49,XXXXY
*https://medlineplus.gov/genetics/condition/49xxxxy-syndrome/
*https://rarediseases.info.nih.gov/diseases/5679/49-xxxxy-syndrome